Archive of past Lupus Mechanisms and Targets Award (LMTA)

2020 Funded Grants

• IgA-containing immune complexes in SLE

  Jessica A. Hamerman, PhD
  Benaroya Research Institute at Virginia Mason
  

• Dynamic regulation of signaling pathways in SLE

  Alessandra Pernis, MD
  The Hospital for Special Surgery
  

• Candidate pathobiont in lupus: genomic variation and pathogenesis

  Gregg J Silverman, MD
  New York University School of Medicine
  

• Redesigning Dnase1L3 for the treatment of systemic lupus erythematosus

  Roger Bryan Sutton, PhD
  Texas Tech University Health Sciences Center
  

2019 Funded Grants

• Targeting the inactive X for correcting dosage imbalances in lupus

  Montserrat Anguera, PhD
  University of Pennsylvania
  

• Intrinsic B cell epigenetic mediators as therapeutic targets in lupus

  Paolo Casali, MD
  University of Texas Health Science Center at San Antonio
  

• Targeting follicular helper T cell metabolism in lupus

  Hongbo Chi, PhD
  St. Jude Children's Research Hospital, Memphis, Tennessee
  

• Cytokine immunoregulatory strategy to target SLE autoreactive B cells

  Hui-Chen Hsu, PhD
  University of Alabama at Birmingham
  

• Ptprz: A therapeutic target for Lupus Nephritis

  Vicki Kelley, PhD
  Brigham and Women's Hospital, Inc.
  

2018 Funded Grants

• Targeting follicular helper T cells in lupus

  Joseph Craft, MD
  Yale School of Medicine
  

• The cyclic GAMP pathway in SLE

  Keith Elkon, MD
  University of Washington
  

• Targeting interferon-stimulated transcription as a novel lupus therapy

  David Levy, PhD
  NYU School of Medicine
  

• PTPN22 Function in Human B Cells and Inhibition to Reset Tolerance in SLE

  Eric Meffre, PhD
  Yale School of Medicine
  

• Targeting peripheral T cell-B cell interactions in SLE

  Deepak Rao, MD, PhD
  Brigham and Women's Hospital
  

• Targeting the CXCR3 chemokine axis in cutaneous lupus

  Jillian Richmond, PhD
  University of Massachusetts Medical School
  

• Mammalian free glycan, glycocalyx and anti-glycan antibody in lupus

  Nan Yan, PhD
  University of Texas Southwestern Medical Center
  

2017 Funded Grants

• The role of bacterial infections in the pathogenesis of lupus

  Roberto Caricchio, MD
  Temple University
  

• Targeting the inactive X chromosome in lupus

  Laura Carrel, PhD
  The Pennsylvania State University College of Medicine
  

• Characterization of STING SAVI gain of function mutations in mice

  Katherine Fitzgerald, PhD
  University of Massachusetts Medical School
  

• ALCAM in Lupus

  Chandra Mohan, MD, PhD
  University of Houston
  

• Defining new targets in lupus through identification of non-coding SNPs

  Peter A. Nigrovic, MD
  Brigham and Women's Hospital, Inc
  

• Targeting endogenous glomerular repair in lupus nephritis

  Janos Peti-Peterdi, MD, PhD
  USC University of Southern California
  

• Finding druggable pathways affected by the R90H-NCF1 SLE risk variants

  Betty Tsao, PhD
  Medical University of South Carolina
  

2016 Funded Grants

• The role of TLR8 in lupus nephritis

  Anne Davidson, MBBS
  Donald and Barbara Zucker School of Medicine at Hofstra/Northwell and Feinstein Institutes for Medical Research
  

• Dissecting the effector function of pathogenic Tfh cells in human lupus

  Rong Fan, PhD
  Yale University
  

• BRISC DUB activity as a novel target for lupus

  Roger Greenberg, MD, PhD
  University of Pennsylvania
  

• A novel target for neutrophil NETosis in lupus skin inflammation

  Ming-Lin Liu, MD, PhD
  University of Pennsylvania Health System
  

• Therapeutic inhibitors of antigen presentation pathways in SLE

  Mark J. Mamula, PhD
  Yale University
  

• Targeting Follicular Helper CD4 T cells in SLE

  Laurence Morel, PhD
  University of Florida College of Medicine
  

• TLR9 regulates Axl dependent migration of autoreactive B cells

  Kerstin Nundel, PhD
  University of Massachusetts Medical School
  

2014 Funded Grants

• Investigating the mechanisms of lupus-associated CNS dysfunction

  Michael Carroll, PhD
  Children's Hospital Boston
  

• Characterization and function of CD4 T cell subsets in lupus

  Joseph Craft, PhD
  Yale University
  

• The contribution of epigenetics to SLE phenotype and outcome

  Lindsey Ann Criswell, MD, MPH
  National Institute of Arthritis and Musculoskeletal and Skin Diseases
  

• The cyclic GAMP pathway in SLE

  Keith Elkon, MD
  University of Washington
  

• Understanding the MoA of low dose IL-2 as a potential therapy for SLE

  Charles Fathman, MD
  Stanford University
  

• IL-2 and IL-33 as therapeutic agents for lupus nephritis

  Shu Man Fu, MD, PhD
  The University of Virginia
  

• Regulation of T follicular helper cells in SLE by E3 ubiquitin ligase Cbl-b

  Wael Jarjour, MD
  The Ohio State University
  

• Estrogen-dependent microRNAs as potential targets for the treatment of SLE

  Caroline Jefferies, PhD
  Cedars-Sinai Medical Center
  

• Role for SHP2 as a therapeutic target for systemic lupus erythematosus

  Maria Kontaridis, PhD
  Beth Israel Deaconess Medical Center
  

• Sex and microbiota influence on immunoregulation and disease in BWF1 mice

  Michele Kosiewicz, PhD
  University of Louisville School of Medicine
  

• Protein S: at the crossroads of thrombosis and inflammation in SLE

  Carla Rothlin, PhD
  Yale University
  

• Therapeutic targeting of FcgRIIb on B cells in SLE

  William Stohl, MD, PhD
  University of Southern California, Keck School of Medicine
  

• Targeting IL-10 producing B cells in SLE

  Betty Tsao, PhD
  Medical University of South Carolina
  

• Role of Tim-1 in kidneys during lupus

  Sheng Xiao, PhD
  Brigham and Women's Hospital
  

• Glycans and glycosylation defects as novel targets in lupus

  Nan Yan, PhD
  UT Southwestern Medical Center
  

2013 Funded Grants

• Influence of BANK1 in the in vivo development of lupus

  Marta Alarcon- Riquelme, MD, PhD
  Fundacion Publica Andaluza Progreso Y Salud
  

• B cell histone modifications and non-coding RNA as targets in lupus therapy

  Paolo Casali, MD
  University of Texas Health Science Center
  

• Aggregated MAVS as a disease mechanism in SLE

  Phillip Cohen, MD
  Temple University
  

• Role of the BAFF receptor BCMA to control B cell homeostasis and tolerance

  Loren D. Erickson, PhD
  University of Virginia
  

• Towards understanding the role of NCF2 in SLE

  Chaim Oscar Jacob, MD
  University of Southern California, Keck School of Medicine
  

• Targeting a dendritic cell-stromal axis in lupus

  Theresa T. Lu, MD, PhD
  The Hospital for Special Surgery
  

• Bradykinins in lupus

  Chandra Mohan, MD, PhD
  University of Houston
  

• High through-put screening to repurpose drugs for lupus therapies

  Laurence Morel, PhD
  University of Florida College of Medicine
  

• Targeting interferogenic signals regulated by SLE risk gene PTPN22

  Erik Jon Peterson, MD
  University of Minnesota Medical School
  

• Metabolism of effector T cells as a target in SLE

  Jeffrey C. Rathmell, PhD
  Vanderbilt University School of Medicine
  

• IRF1 decoy treatment

  Kathleen Sullivan, MD, PhD
  The Children's Hospital of Philadelphia
  

• Identifying functional variants that underlie SLE susceptibility

  Edward K. Wakeland, PhD
  UT Southwestern Medical Center
  

2012 Funded Grants

• Inhibition of IL-6 trans-signaling in SLE

  Anne Davidson, MBBS
  Donald and Barbara Zucker School of Medicine at Hofstra/Northwell and Feinstein Institutes for Medical Research
  

• TREM-1 in lupus nephritis

  Laurie Davis, PhD
  UT Southwestern Medical Center
  

• The CR2:C3d receptor: ligand interaction as a therapeutic target in lupus

  Michael Holers, MD
  University of Colorado Denver, AMC and DC
  

• New targets for treatment of glucocorticoid-resistant lupus

  Michael Karin, PhD
  University of California, San Diego
  

• Immunoproteasome selective inhibitors for lupus treatment

  Gang Lin, PhD
  Weill Cornell Medical College
  

• CD4 T cell metabolism in SLE: characterization and target identification

  Laurence Morel, PhD
  University of Florida College of Medicine
  

• Targeting DNA polynucleotides in lupus

  Fred Perrino, PhD
  Wake Forest School of Medicine
  

• The roles of the individual elements of the BAFF axis in murine SLE

  William Stohl, MD, PhD
  University of Southern California, Keck School of Medicine
  

• The role of immune complexes and BAFF in promoting atherosclerosis in lupus

  Barbara Vilen, PhD
  The University of North Carolina at Chapel Hill