A cure for lupus has yet to be identified. Its complex and heterogenous symptoms are currently managed by mostly non-specific anti-inflammatory and immunosuppressive agents. To improve the lives of lupus patients, the Lupus Research Alliance supports outstanding scientists to investigate the fundamental causes and underlying mechanisms of lupus that could lead to the development of safer and more effective therapies. We fund innovative foundational and translational projects that focus on understanding disease heterogeneity to enable patient stratification by active disease mechanisms. We seek to engage diverse scientific researchers who apply novel approaches and cutting-edge technologies to identify molecular pathways or novel targets that could lead to prevention, improved diagnostics and treatments, and ultimately a cure for lupus.