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SAB

Weill Cornell Graduate School of Medical Sciences

Gary Koretzky, MD, PhD is Vice Provost for Academic Integration at Cornell University and a Professor of Medicine at Weill Cornell Medicine.  Previously, he was the Francis C. Wood Professor of Medicine, Vice Chair and Chief Scientific Office of the Department of Medicine, Investigator and Director of the Signal Transduction Program of the Abramson Family Cancer Research Institute at the University of Pennsylvania.

Dr. Koretzky received his AB from Cornell University (’78) and obtained his MD and PhD (Immunology) degrees at the University of Pennsylvania (’84).  Dr. Koretzky then pursued clinical training in Internal Medicine and Rheumatology at the University of California at San Francisco. He re-entered the laboratory as a postdoctoral fellow, examining the molecular events associated with T cell activation. Dr. Koretzky moved to the University of Iowa in 1991 where he continued his research examining the biochemistry and molecular biology of signal transduction in hematopoietic cells until he moved to the University of Pennsylvania in 1999.

Koretzky’s research aims to better understand the signal transduction events that occur following engagement of the T cell antigen receptor.  He has been continuously funded by the National Institutes of Health since establishing his independent research group, as the laboratory has expanded its interests to study more globally the molecular events important for immune cell development, differentiation and function.  Initial studies focused on the CD45 tyrosine phosphatase as a positive regulator of immunoreceptor signaling.  This work led naturally to an examination of the key biochemical events that occur following receptor engagement.  The Koretzky lab approach was to identify novel regulators of signal transduction following T cell receptor ligation with studies leading to the isolation, characterization, and molecular cloning of several adapter molecules, which are critical for integration of signaling pathways.  The laboratory has identified 3 such molecules including SH2 domain-containing leukocyte protein of 76 kDa (SLP-76), adhesion and degranulation-promoting adapter protein (ADAP) and promyelocytic leukemia RARa-regulated adapter molecule-1 (PRAM-1).  There are ongoing projects studying the role of each of these molecules not only in T cells but also in other hematopoietic cells.  In addition to studies of these positive regulators of immune signaling, the Koretzky laboratory has also had a long standing interest in signals that interfere with activation events in T cells.  This interest led to studies of FAS and FAS ligand and to the role of diacylglycerol kinases as terminators of lymphocyte activation.

Dr. Koretzky has published more than 200 research articles.  He is a past President of the American Society of Clinical Investigation (2000) and Councilor of the Association of American Physicians (2008-2012), is a Fellow of the American Association for the Advancement of Science (2004), a member of the Institute of Medicine of the National Academies (2008), a Fellow of the American Academy of Arts & Sciences (2012) and serves as the Editor-in-Chief of Immunological Reviews (2002-present).

Genentech, A Member of the Roche Group

Dr. Andrew Chan is Senior Vice President of Research-Biology at Genentech, Inc (GNE) where he has overseen biological research in oncology, immunology, neuroscience, infectious diseases, and biotherapeutic discovery for over the past decade. He is an accomplished leader in target discovery, drug discovery, and drug development. In his role, he has governance responsibilities over both GNE’s research and clinical portfolio through Phase 2 proof-of-concept studies.

Dr. Chan is a leader in biotherapeutics and has authored key reviews for academic and biopharmaceutical communities integrating lessons learned about disease pathogenesis and mechanisms of therapy. He is also a leader in advocating and implementing precision medicine strategies through biomarker discovery and development. Dr. Chan’s laboratory focuses on how our immune systems protect us against foreign pathogens yet can cause autoimmune and inflammatory diseases. He has published over 100 research papers, review articles and books. Dr. Chan himself is a co-inventor of ocrelizumab (Ocrevus™), the first B-cell directed therapy approved by the FDA for treatment of both relapsing and progressive forms of multiple sclerosis.

Dr. Chan plays key roles to bridge academia, patient advocacy, and industry. He presently serves as Chair of the Executive Advisory Board of the Chemistry Life Processes Institute (Northwestern University), member of the National Council at Washington University School of Medicine, and member of the Biopharma Advisory Board at Washington University. He is member of the National Medical and Scientific Advisory Board of the Arthritis Foundation and the Lupus Research Alliance. He is also Chair of the Medical and Scientific Committee of the San Francisco Arthritis Foundation.

Dr. Chan received his BA and MS degrees in chemistry at Northwestern University and MD and PhD degrees from Washington University (WUSM). He completed his internal medicine residency at Barnes Hospital and rheumatology fellowship at UCSF. He joined the faculty at WUSM in the Departments of Medicine and Pathology and was a member of the Howard Hughes Medical Institute. He is an elected member of the American Association of Physicians, American Society for Clinical Investigation, Henry Kunkel Society and a Pew Scholar. He is recipient of the Lee Howley Sr Prize in arthritis research, the Northwestern alumni medal, the Washington University School of Medicine Alumni Achievement award, the American Federation for Aging Research Chairman’s Award of Distinction, and the Guin Warnock Award from the Arthritis Foundation. He is also presently Associate Professor of Medicine at UCSF.

Consultant

Dr. Collins has been a scientific leader in the biopharmaceutical industry with 28 years of experience leading research efforts in industry to discover and develop new small molecule and protein therapeutics for the treatment of inflammatory diseases.

Dr. Collins served as Chief Scientific Officer and Vice President of the Immunology and Autoimmunity Research Unit for Pfizer in Cambridge MA from 2009 until her retirement in 2012.  Prior to this, she was Vice President of Inflammation Discovery Research at Wyeth.

She currently serves on the Scientific Advisory Board of the Lupus Research Alliance and is a visiting scientist at Harvard Medical School.

Dr. Collins completed undergraduate, graduate and postdoctoral work at SUNY at Stony Brook, Wesleyan University, and the Carnegie Institute of Washington. She joined the biotechnology company Genetics Institute in 1983.

Originally trained in molecular biology and genetics, she began work in Immunology in 1987 after a sabbatical at Harvard Medical School.

Her career encompassed both the biotechnology and pharmaceutical environments due to the acquisition of Genetics Institute by Wyeth in 1996, and the acquisition of Wyeth by Pfizer in 2009.

Dr. Collins’s research interests have focused on the discovery and therapeutic application of novel pathways for modulating immune responses.

Dr. Collins is an author on over 100 scientific publications and an inventor on 35 issued US patents.  She has served as a reviewer for multiple scientific journals and granting committees.

She has enjoyed collaborative interactions with scientists in the Immunology community, making scientific contributions to the field, mentoring the next generation of scientists, and contributing to improvements in healthcare.

Oklahoma Medical Research Foundation/Oklahoma University Health Sciences Center

Judith A. James, MD, PhD, is Chair of the Arthritis and Clinical Immunology Program and holds the Lou Kerr Chair in Biomedical Research at the Oklahoma Medical Research Foundation.  Dr. James is also the Associate Vice Provost for Clinical and Translational Science and Professor of Medicine and Pathology at the University of Oklahoma Health Sciences Center.

Dr. James’ research interests focus on understanding the pathogenesis, prediction, prevention and precision treatment of systemic lupus erythematosus and related disorders, the evolution and pathogenic mechanisms of autoantibodies in systemic rheumatic disease, and the interplay of genetic risk and environmental responses in systemic autoimmunity. Her work has made seminal contributions to understanding how autoimmune diseases start and the concept of humoral epitope spreading. She has published over 330 articles in journals such as the New England Journal of Medicine, Nature Medicine, Journal of Experimental Medicine, Annals of Rheumatic Disease and Arthritis and Rheumatology for example.

Dr. James currently serves as the principal investigator for several large, multi-investigator NIH-funded grants, such as the U54 Oklahoma Shared Clinical & Translational Resources from NIGMS, UM1 Autoimmunity Center of Excellence from NIAID, and P30 Rheumatic Disease Research Cores Center from NIAMS. Dr. James has conducted lectures for the American College of Rheumatology, International Systemic Lupus Erythematosus Meetings, among others.

Dr. James has received several prestigious awards including the the Stanley J. Korsmeyer award from the American Society for Clinical Investigation, the Presidential Early Career Award for Scientists and Engineers and the Dubois’ Award from the American College of Rheumatology. She has served as a member of NIAMS Council with the National Institutes of Health and as the elected Secretary-Treasurer of the American Society of Clinical Investigation. She has served on several other NIH advisory committees and chaired an NIH Roundtable regarding preclinical autoimmunity. Dr. James also was selected to provide testimony supporting the NIH at the Noel Laureates’ Hearing for the US Senate Appropriations Subcommittee.

Dr. James received her medical degree and PhD in Immunology from the Oklahoma Health Sciences Center and is a board certified adult rheumatologist. She continues to practice adult rheumatology, focusing on SLE, incomplete lupus, and related rheumatic diseases.

 

Director, Life Sciences Institute, UBC

Professor, Dept of Medical Genetics, UBC

Canada 150 Research Chair in Functional Genetics

Professor of Genetics, University of Vienna

Honorary Professor, Chinese Academy of Medical Sciences & Qingdao University

Guest Professor, Medical University of Vienna

Adjunct Professor, Dept of Immunology, University of Toronto

 

 Josef Martin Penninger, born in Gurten, Austria, is an Austrian geneticist and the Canada 150 Research Chair in Functional Genetics. Dr. Penninger is currently the Director of the Life Sciences Institute (LSI) at the University of British Columbia. He studied medicine at the University of Innsbruck in Austria. From 1990 to 1994 he worked as post-doctoral fellow at the Ontario Cancer Institute, thereafter until 2002 at the Department of Immunology and Medical Biophysics at the University of Toronto. As Principal Investigator of Amgen, his independent lab contributed to the development of the antibody Denosumab for bone loss and also found the first connection for RANKL to mammary gland development in pregnancy and breast cancer. In 2002, he moved to Vienna, Austria to start and develop the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), which has become one of the prime research centers in the world. Dr. Penninger envisions to recreate this environment at the LSI to nurture and train the best and brightest young minds of UBC scholars. His major accomplishments include pioneering insights into the molecular basis of osteoporosis, breast cancer, and linking ACE2 and SARS or COVID-19-casing Coronavirus infections to lung failure. He has published extensively in several multidisciplinary scientific journals, with over 60 publications in Cell, Nature, and Science. Josef has received numerous awards including the Wittgenstein Prize of the Austrian Federal Government, the Descartes Prize for Research, the Ernst Jung Prize for Medical Excellence, the Innovator Award of the US Department of Defense, and most recently the Austrian Cross of Honor for Science and Art First Class. Currently he holds a Canada 150 Chair.

University of Washington School of Medicine

 Dr. Rawlings graduated Magna Cum Laude in Biological Sciences from Davidson College, and received his M.D. from the University of North Carolina. He completed residency and chief residency in pediatrics at UCSF, and Pediatric Rheumatology/Immunology subspecialty training at Children’s Hospital Los Angeles. He pursued post-doctoral research as an intramural fellow at the NIH and in the HHMI, UCLA. Formerly a member of the UCLA faculty, Dr. Rawlings joined the University of Washington in 2001. He directs the Center for Immunity and Immunotherapies at Seattle Children’s Research Institute and is also chief of the Division of Immunology overseeing the immunodeficiency clinical program at Seattle Children’s Hospital. Dr. Rawlings has received numerous awards including the Seattle Children’s Guild Association Endowed Chair in Pediatric Immunology, Tom Hansen Investigator in Pediatric Innovation Endowment, and election to the American Society for Clinical Investigation and Association of American Physicians.

His primary research interests include dysregulated lymphoid development and signaling leading to immunodeficiency, autoimmunity and/or lymphoid malignancies, and the development of gene therapy for immune diseases. His laboratory uses expertise in basic and clinical immunology, signal transduction and gene editing to understand how altered signals can lead to immunologic disease, with the goal of developing translational therapies that specifically modulate key pathways.

 

Hospital for Special Surgery

Dr. Jane Salmon is Professor of Medicine and Professor of Obstetrics and Gynecology at Weill Cornell Medical College and the Collette Kean Research Professor at Hospital for Special Surgery.

Dr. Salmon graduated magna cum laude from New York University and earned a medical degree in 1978 from the College of Physicians and Surgeons of Columbia University, where she was the first woman enrolled in their Medical Scientist Training Program. She completed training in internal medicine at The New York Hospital and in rheumatology at Hospital for Special Surgery, and has been an HSS faculty member since 1983. Dr. Salmon has served on the Board of Directors of the American College of Rheumatology and on the NIH Advisory Boards for the North American Rheumatoid Arthritis Consortium and the Lupus Multiplex Registry. Dr. Salmon was co-editor of Arthritis and Rheumatism and is currently an Associate Editor of Annals of Rheumatic Diseases. At Hospital for Special Surgery, she is a Director of the Lupus and APS Center of Excellence, co-Director of the Mary Kirkland Center for Lupus Research, and Director of the FOCIS Center of Excellence.

Dr. Salmon’s research has focused on elucidating mechanisms of tissue injury in lupus and other autoimmune diseases. Her basic and clinical studies have expanded our understanding of pregnancy loss and organ damage in SLE and the determinants of disease outcome in lupus patients with nephritis, pregnancy, and cardiovascular disease.

 

Cold Spring Harbor Laboratory

Jason Williams is Assistant Director, Inclusion and Research Readiness at the Cold Spring Harbor Laboratory DNA Learning Center where he develops national biology education programs. Jason leads education, outreach, and training for CyVerse (US national cyberinfrastructure for the life sciences) and has trained thousands of students, researchers and educators in bioinformatics, data science, and molecular biology. Jason’s focus has been developing bioinformatics in undergraduate education and career-spanning learning for biologists. Jason is founder of LifeSciTrainers.org – a global effort to promote community of practice among professionals who develop short-format training for life scientists. Jason is advisory to cyberinfrastructure, bioinformatics, and education projects and initiatives in the US, UK, Europe, and Australia. He is also a teacher at the Yeshiva University High School for Girls.

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