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SCIENTIFIC PUBLICATIONS BY ALR FUNDED RESEARCHERS

In Vivo Validation And Characterization Of Allelic Variants In Lupus

Means, Terry K. Ph.D.

Massachusetts General Hospital

Genome-wide association studies such as the SLE Genetics consortium have identified numerous genetic variants associated with an increased risk of lupus. However, a major barrier in lupus research is the lack of a rapid high-throughput system, a special kind of technology that can validate these candidate variants and determine if they truly do contribute to lupus.

Dr. Means and his team have developed and optimized a novel approach to express human, lupus-related genes in animal models. This approach can rapidly generate animal models that harbor an immune system developed with cells that express human genetic mutations. 

With this grant, the team will use their animal models to study the effects of human lupus-related risk genes on the development and progression of lupus. 

What this study means for people with lupus: These studies will provide a rich pipeline of molecular targets that could be fast-tracked for the development of lupus-related treatments.


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