Funded Research

Lupus Mechanisms and Targets Award (LMTA)

The Lupus Mechanisms and Targets Award (LMTA) ($600,000 for three years) supports research focused on the identification and/or investigation of molecular pathways or targets that could lead to new or improved therapies for people with lupus.

2020 Funded Grants

In situ adaptive immunity in lupus tubulointerstitial inflammation

Marcus Clark, MD
The University of Chicago

IgA-containing immune complexes in SLE

Jessica A. Hamerman, PhD
Benaroya Research Institute at Virginia Mason

Dynamic regulation of signaling pathways in SLE

Alessandra Pernis, MD
The Hospital for Special Surgery

Candidate pathobiont in lupus: genomic variation and pathogenesis

Gregg J Silverman, MD
New York University School of Medicine

Redesigning Dnase1L3 for the treatment of systemic lupus erythematosus

Roger Bryan Sutton, PhD
Texas Tech University Health Sciences Center

Targeting the inactive X for correcting dosage imbalances in lupus

Montserrat Anguera, PhD
University of Pennsylvania

Intrinsic B cell epigenetic mediators as therapeutic targets in lupus

Paolo Casali, MD
University of Texas Health Science Center at San Antonio

Targeting follicular helper T cell metabolism in lupus

Hongbo Chi, PhD
St. Jude Children's Research Hospital, Memphis, Tennessee

Cytokine immunoregulatory strategy to target SLE autoreactive B cells

Hui-Chen Hsu, PhD
University of Alabama at Birmingham

Ptprz: A therapeutic target for Lupus Nephritis

Vicki Kelley, PhD
Brigham and Women's Hospital, Inc.

Relieving ER stress in lupus neutrophils

Jason Knight, MD, PhD
University of Michigan, Ann Arbor

Targeting follicular helper T cells in lupus

Joseph Craft, MD
Yale School of Medicine

The cyclic GAMP pathway in SLE

Keith Elkon, MD
University of Washington

Targeting interferon-stimulated transcription as a novel lupus therapy

David Levy, PhD
NYU School of Medicine

PTPN22 Function in Human B Cells and Inhibition to Reset Tolerance in SLE

Eric Meffre, PhD
Yale School of Medicine

Targeting peripheral T cell-B cell interactions in SLE

Deepak Rao, MD, PhD
Brigham and Women's Hospital

Targeting the CXCR3 chemokine axis in cutaneous lupus

Jillian Richmond, PhD
University of Massachusetts Medical School

Mammalian free glycan, glycocalyx and anti-glycan antibody in lupus

Nan Yan, PhD
University of Texas Southwestern Medical Center

The role of bacterial infections in the pathogenesis of lupus

Roberto Caricchio, MD
Temple University

Targeting the inactive X chromosome in lupus

Laura Carrel, PhD
The Pennsylvania State University College of Medicine

Characterization of STING SAVI gain of function mutations in mice

Katherine Fitzgerald, PhD
University of Massachusetts Medical School

ALCAM in Lupus

Chandra Mohan, MD, PhD
University of Houston

Defining new targets in lupus through identification of non-coding SNPs

Peter A. Nigrovic, MD
Brigham and Women's Hospital, Inc

Targeting endogenous glomerular repair in lupus nephritis

Janos Peti-Peterdi, MD, PhD
USC University of Southern California

Finding druggable pathways affected by the R90H-NCF1 SLE risk variants

Betty Tsao, PhD
Medical University of South Carolina

A novel target for neutrophil NETosis in lupus skin inflammation

Ming-Lin Liu, MD, PhD
University of Pennsylvania Health System

Targeting Follicular Helper CD4 T cells in SLE

Laurence Morel, PhD
University of Florida College of Medicine

Archive of lmta grants

Distinguished Innovator Award (DIA) Lupus Mechanisms and Targets Award (LMTA) Lupus Innovation Award (LIA) LRA-BMS Accelerator Awards (BMS) Common Mechanisms in Autoimmunity Global Team Science Award

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