Common Mechanisms in Autoimmunity

2025 Funded Grants

• Mechanisms of B Cell Polyreactivity in Autoimmunity: Toward Precision Immunotherapy

  Elena Hsieh, MD
  University of Colorado Anschutz School of Medicine
  

• Dock2-mediated T cell migration as a targetable shared mechanism in autoimmunity

  Alok Joglekar, PhD
  University of Pittsburgh
  

• Dissecting HLA Mechanisms in T1D, SLE, and MS Through High-Throughput Self-Antigen Profiling

  Aly Khan, PhD
  University of Chicago
  

• Monitoring CD4+ T-cell responses in T1D, MS and SLE

  Stuart Mannering, PhD
  St. Vincent's Institute of Medical Research
  

• Understanding common tissue tolerance mechanisms in autoimmunity

  Gary Reynolds, MBBS, PhD
  Massachusetts General Hospital
  

• Anti-CD71 immunotherapy to restore T cell homeostasis in autoimmunity

  Kelsey Voss, PhD
  University of Virginia
  

• Understanding role of B cells in the pathogenesis of Type 1 Diabetes and Multiple Sclerosis

  Yoshiaki Yasumizu, MD, PhD
  Yale School of Medicine
  

2021 Funded Grants

• Linking multiple disease compartments in T1D and multiple sclerosis

  Amit Bar-Or, MD
  University of Pennsylvania
  

• Identification of pathogenic pathways through genomic engineering to identify shared genetic effects on people with T1D, SLE, and MS

  Chris Cotsapas, PhD
  Yale School of Medicine
  

• Analysis of antigen specific T cells in response to immune therapies in MS and T1D

  Kevan Herold, MD
  Yale School of Medicine
  

• COMET common mechanisms in autoimmunity

  Thomas Pieber, MD
  Medical University of Graz, Austria
  

• Dissecting the genetics and host interactions of EBV-related autoimmunity

  William Robinson, MD, PhD
  Stanford University
  

• 3D and single-cell epigenome technologies for autoimmune disease

  Ansuman Satpathy, MD, PhD
  Stanford University
  

• Single-cell genomics dissection of common immune networks driving autoimmunity

  Alexandra-Chloé Villani, PhD
  Massachusetts General Hospital and Harvard Medical School​
  

• NR4A family as markers and mediators of B cell tolerance across autoimmune diseases: from antigen discovery to treatment

  Julie Zikherman, MD
  University of California, San Francisco