Aurinia Announces Voclosporin Meets 48-Week Remission Endpoints
Aurinia Pharmaceuticals Inc. (NASDAQ:AUPH / TSX:AUP) (“Aurinia” or the “Company”), a clinical stage biopharmaceutical company focused on the global immunology market, today announced top-line results from its Phase IIb AURA-LV (AURA) study in lupus nephritis (LN). At 48 weeks, the trial met the complete and partial remission (“CR”/ “PR”) endpoints, demonstrating statistically significantly greater CR […]
LIC Accomplishments
As of December 2019 Determinants of ANA Expression in Patients with Lupus PI: David Pisetsky (Duke University) Co-PIs: Megan Clowse (Duke University), Peter Lipsky (AMPEL BioSolutions LLC), Dr. Brad Rovin, Ohio State University Project Status: Completed in 2018 The goal of this study was to assess the expression of antinuclear antibodies (ANA) in SLE, focusing […]
Advancing Research Exponentially
August 14, 2018 Advancing Research Exponentially An Update on AMP by Jill Buyon, MD Lupus nephritis (LN), one of the dreaded complications of lupus, causes patients to suffer, sometimes for decades, with no new treatment in sight. But now is the time to leverage technology for major advances, which is exactly what the Accelerating Medicines […]
Living in a Disadvantaged Neighborhood Lowers Follow-up Care
March 4, 2020 A new study showed that living in a disadvantaged neighborhood predicts poor retention (follow-up) care for people with lupus. Retention was defined specifically has having two out-patient doctor visits or lab tests such as measuring complement levels. Researchers looked at the records of 397 patients with lupus in terms of age, sex, […]
KZR-616 Shows Promise According to Results Reported at EULAR
Kezar Life Sciences announced positive results from the MISSION Phase 1 study testing the investigational KZR-616 as a treatment for lupus. The presentation was at the European League Against Rheumatism (EULAR) 2019 annual meeting. The primary goal of the study was to assess if KZR-616 is safe and well tolerated. The study also looked at […]
LRA Congratulates Aurinia on Published Results with FDA-Approved Lupkynis™
May 10, 2021 The highly prestigious medical journal The Lancet published the results of Aurinia’s Phase 3 AURORA 1 study testing Lupkynis™ (voclosporin) in adults with lupus nephritis. Lupkynis was approved by the U.S. Food and Drug Administration based on these data. The AURORA 1 study results showed that Lupkynis in combination with the commonly used […]
Global Team Science Award
The Global Team Science Award ($3 million over three years) will support collaborative, and highly synergistic projects by international, multidisciplinary teams that push the boundaries of innovation to bridge research and clinical initiatives in lupus. 2023 Funded Grants Identifying Genetic and Immunological Determinants of Childhood Lupus Nephritis Elena Hsieh, M.D., Jean-Laurent Casanova, M.D., Ph.D., Debashis […]
Ferroptosis
The term ferroptosis is derived from the Greek word ptosis, meaning “a fall,” and ferrum, the Latin word for iron. It describes a form of regulated cell death in which iron appears to be a factor. Many lupus experts believe that ferroptosis may play an important role in lupus nephritis.
Edema
Edema means swelling caused by excess fluid in the body’s tissues. It usually occurs in the feet, ankles and legs, but it can involve the entire body. Edema can be a symptom of lupus nephritis. Source: MedlinePlus.gov, NIH.gov
Electrolytes
Electrolytes are minerals in your body that have an electric charge. They are in your blood, urine and body fluids. Maintaining the right balance of electrolytes helps your body’s blood chemistry, muscle action and other processes. Sodium, calcium, potassium, chlorine, phosphate and magnesium are all electrolytes. You get them from the foods you eat and […]
Kidney
Your kidneys are two bean-shaped organs, each about the size of your fists. They are located near the middle of your back, just below the rib cage. Inside each kidney about a million tiny structures called nephrons filter blood. They remove waste products and extra water, which become urine. The urine flows through tubes called […]