Targeted Research Program on Engineered Cell Therapies for Lupus (TRP-ECT)

2024 Funded Grants

• ACCELERATE

  Reuben Benjamin, MBBS, FRCPath, PhD
  King's College London
  

• A Novel CAR T Therapy for Selective Depletion of Autoimmune B cell in Lupus

  Vijay Bhoj, MD, PhD
  University of Pennsylvania
  

• Restoration of Immune Cell Homeostasis in Tissue via CD19 CAR-T Cell Mediated B Cell Clearance in SLE

  Ricardo Grieshaber-Bouyer, MD, PhD
  University Hospital Erlangen
  

• Correlative Biomarkers in the REACT-01 Pediatric Lupus CD19 CAR Trial

  Shaun Jackson, MD, PhD
  Seattle Children's Hospital
  

• OX40L Targeted Chimeric Antigen Receptor (CAR) Tregs for SLE

  Leslie Kean, MD, PhD
  Boston Children's Hospital
  

• Optimized CAR-T Therapy for Lupus

  Richard O’Neil, PhD
  Medical University of South Carolina
  

• GMP-Ready Smith-Specific Regulatory T Cell Therapy to Treat Lupus Nephritis

  Joshua Ooi, PhD
  Monash University
  

• Allogenic BAFF CAR-NK Cell Therapy for Lupus

  Reshmi Parameswaran, PhD
  Case Western Reserve University - School of Medicine
  

• Sensitive and Bispecific Chimeric TCR for SLE Therapy

  Stanley Riddell, MD
  Fred Hutchinson Cancer Center
  

• Mechanistic Studies of CART Cell-Induced B Cell Depletion in SLE

  Ignacio Sanz, MD
  Emory University
  

• A Novel CART Cell Selectively Targeting Age-Associated B Cells to Treat Lupus

  Mark Shlomchik, MD, PhD
  University of Pittsburgh