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Tag: camptothecin

Existing Cancer Drug May Lower Inflammation in Autoimmune Diseases Like Lupus

December 14, 2020 In a recent study published in the Journal of Immunology, LRA-funded researcher Dr. John Zhang at Medical University of South Carolina found that a protein called Fli-1 causes immune cells to produce a molecule that causes inflammation. When Fli-1 was hindered by the chemotherapeutic drug camptothecin, immune cells produced fewer inflammatory molecules. […] Read More

Low-Dose Chemotherapy May Help Lupus Nephritis

February 22, 2021 In a recent study published in Arthritis & Rheumatology, LRA-funded researcher Dr. Xian Zhang found that a low dose of the chemotherapy drug topotecan reduced the inflammation and kidney damage of lupus nephritis in mice with lupus. Topotecan was as effective as high doses of cyclophosphamide, another chemotherapy that’s currently used to […] Read More
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