University of Graz, Austria
Dr. Pieber and his team will apply highly sophisticated computerized machine-learning approaches on existing data from people with type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis and healthy volunteers, to identify the changes in different immune cells that are shared between the autoimmune diseases or unique to each. (Machine learning are computer programs that improve automatically through experience, which can help researchers find patterns from large-scale datasets.) This will generate a deeper understanding of commonalities and differences of immunological patterns in type 1 diabetes, lupus, multiple sclerosis, and rheumatoid arthritis, and will identify important pathways in immune cells that can then be tested for potential therapies.