Biomarker identification in SLE identified via microbiome-host interactions
Lupus causes an immune response targeted against normal human cells. However, it is not known what triggers this response to start. Recently, Dr. Brito devised a method to determine how proteins produced by bacteria found in individuals’ guts, impact the normal function of immune cells. Although it is known that the microbiomes of patients with lupus have notable differences than healthy patients, now, with much higher resolution, Dr. Brito’s team will determine the specific effects of these microbiome differences. Her team will test individual gut bacteria-derived proteins for their ability to change immune cell function and look for these proteins in the blood of patients with lupus.
What this study means for people with lupus
This study will help identify new markers of lupus that could function as targets for development of potential treatments. If these markers are found in the blood of lupus patients, they may also be useful for diagnosing lupus.