June 19,2019 Partly funded by the Lupus Research Alliance, new results presented at the European Congress of Rheumatology (EULAR) 2019 suggest that some potential cancer treatments may also help patients with lupus. Dr. Amr Sawalha of the University of Pittsburgh and colleagues have discovered a similarity between immune cells in lupus and some kinds of […] READ MORE
June 20, 2019 Michael Lauria knows only too well that lupus is not just a woman’s disease – he was diagnosed in the prime of his life – when he was just 32 years old. And he is counting on the Lupus Research Alliance to find the answers that will change his life. Young, fit, […] READ MORE
Boston, MA. June 19, 2019. The Lupus Research Alliance has awarded its 2019 Lupus Insight Prize to Ignacio Sanz, MD, for discovering that certain little-understood immune system cells are a major source of the harmful proteins that promote lupus symptoms. His work could spark new treatments for the disease and help doctors determine which patients […] READ MORE
June 12, 2019 A study presented at EULAR showed that ongoing maintenance therapy with the immunosuppressive drug cyclosporine helped lower proteinuria — the level of protein in urine — faster than other immunosuppressive drugs mycophenolate mofetil or azathioprine in people with lupus nephritis. The three were comparable in their ability to cause remission of Lupus […] READ MORE
June 18, 2019 A common type of bacteria living in the gut may spark a common lupus complication called antiphospholipid syndrome, a study partly funded by the Lupus Research Alliance shows. Antiphospholipid syndrome can lead to blood clots and miscarriages. Led by Dr. Martin Alexander Kriegel of Yale School of Medicine, the research may also […] READ MORE
Kezar Life Sciences announced positive results from the MISSION Phase 1 study testing the investigational KZR-616 as a treatment for lupus. The presentation was at the European League Against Rheumatism (EULAR) 2019 annual meeting. The primary goal of the study was to assess if KZR-616 is safe and well tolerated. The study also looked at […] READ MORE
Results of two analyses from a Phase 2 study of Stelara® (ustekinumab) in lupus showed the drug’s effectiveness over one year. Both highlight the benefit of ustekinumab on disease activity and the rate of severe flares. Ustekinumab reduced the rate of severe flares four times as much as placebo by week 24. The rate of […] READ MORE
June 13, 2019 A study published in Arthritis & Rheumatology found that rituximab was helpful as a maintenance therapy for tough-to-treat lupus patients. Maintenance treatment refers to one designed to help a main treatment work. Rituximab is approved by the U.S. Food and Drug Administration for two types of cancer. It is sold by the […] READ MORE
MADRID, Spain. June 13, 2019 – Results of the first clinical trial sponsored by the Lupus Research Alliance and conducted through its Lupus Clinical Investigators Network (LuCIN) were presented today at the European Congress of Rheumatology (EULAR) 2019. Entitled VAlidation in LUpus of an Electronic Patient Reported Outcomes Tool (VALUE), the study showed that a […] READ MORE
June 13, 2019 New results from a clinical study with healthy volunteers found the investigational compound NKTR-358 safe and well-tolerated, providing support for testing it as a treatment for autoimmune diseases such as lupus. Researchers have known that impaired production of interleukin-2 (IL-2) and dysfunctioning regulatory T cells called Tregs are key to breaking down […] READ MORE
Normally helpful immune system cells become harmful in patients with lupus. With a Novel Research Grant from the LRA, a team led by Dr. Frances Lund of the University of Alabama at Birmingham and Dr. Ignacio Sanz of Emory University in Atlanta and has discovered one possible reason why. The immune cells known as B […] READ MORE
NEW YORK, NY. June 11, 2019. The Lupus Research Alliance is pleased to share positive topline results from a Phase 2 clinical study of a potential new treatment for proliferative lupus nephritis, the most severe form of kidney damage caused by lupus. Genentech, a member of the Roche Group, reported that at one year their […] READ MORE
