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Interferon- Treatment of Female (NZW  BXSB)F1 Mice Mimics Some but Not All Features Associated With the Yaa Mutation - Dr. Anne Davidson

Male (NZW x BXSB)F1 mice develop antiphospholipid syndrome (APS) and proliferative glomerulonephritis that is markedly accelerated by the Yaa locus encoding an extra copy of Tlr7. Female (NZW x
BXSB)F1 mice with only 1 active copy of Tlr7 develop late-onset glomerulonephritis but not APS. Because a major function of Toll-like receptor 7 is to induce type I interferons (IFNs), our goal was to determine whether IFN can induce or accelerate the manifestations of systemic lupus erythematosus (SLE) in female (NZW x BXSB)F1 mice.

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Source: Alliance for Lupus Research
Funded Research



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