HOME
Leading the way to a cure

SCIENTIFIC PUBLICATIONS BY ALR FUNDED RESEARCHERS

Function2Gene: A gene selection tool to increase the power of genetic association studies by utilizing public databases and expert knowledge - Chaim O Jacob

Background: Many common disorders have multiple genetic components which convey increased susceptibility. SNPs have been used to identify genetic components which are associated with a
disease. Unfortunately, many studies using these methods suffer from low reproducibility due to lack of power.

Results: We present a set of programs which implement a novel method for searching for diseaseassociated genes using prior information to select and order genes from publicly available databases
by their prior likelihood of association with the disease. These programs were used in a published study of childhood-onset SLE which yielded novel associations with modest sample size.

Conclusion: Using prior information to decrease the size of the problem space to an amount commensurate with available samples and resources while maintaining appropriate power enables
researchers to increase their likelihood of discovering reproducible associations.

...

Read the Full article here

Source: Alliance for Lupus Research
Funded Research

 



1.5 million

people in the U.S. have Lupus.

90 million

dollars committed to lupus research by the Alliance for Lupus Research.


We're walking across the United States to raise awareness and funds for lupus research.

Can't make it? Join our National Virtual Walk to participate anytime, anywhere.


Show your support by visiting the Alliance for Lupus Research online store. Discover the perfect gift, or prepare for a walk with our selection of apparel and accessories.

Powered by Convio
nonprofit software