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A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus - Virginia Pascual

The analysis of patient blood transcriptional profiles offers a means to investigate the immunological mechanisms relevant to human diseases on a genome- wide scale. In addition, such studies provide a basis for the discovery of clinically relevant biomarker signatures. We designed a strategy for microarray analysis that is based on the identification of transcriptional modules formed by genes coordinately expressed in multiple disease data sets. Mapping changes in gene expression at themodule level generated disease-specific transcriptional fingerprints that provide a stable framework for the visualization and
functional interpretation of microarray data. These transcriptional modules were used as a basis for the selection of biomarkers and the development of a multivariate transcriptional indicator of disease progression in patients with systemic lupus erythematosus. Thus, this work describes the implementation andapplication of amethodology designedto support systems-scale analysis of the human immune system in translational research settings.

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Source: Alliance for Lupus Research
Funded Research



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