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Alliance for Lupus Research
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John Harley, MD, PhDJennifer Anolik, MD, PhDAnne Davidson, MD

The Latest Lupus Research and Drug Developments

 

The Alliance for Lupus Research (ALR) has worked to fund biomedical research for more than 10 years into the cause and treatment of lupus, and is committed to identifying new and improved treatments for the disease. After decades with no new treatments, the ALR is proud to be a catalyst for increased attention to lupus research and will continue its aggressive efforts until new therapies are brought to market. The chart below highlights agents currently being studied in people with lupus. The ALR has supported research leading to the development of more than a third of these agents in the clinical pipeline (marked with an asterisk below). The solution to lupus is research! More information about lupus and the ALR can be found by visiting www.lupusresearch.org.

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New Lupus Therapeutics

Drug Name  

Company or Organization  

Anti-interferon alpha therapies

Medi-545*

MedImmune

 

rhuMAb IFNalpha*  (Rontalizumab)

Genentech

 

NNC 0152-0000-0001*

Novo Nordisk

Anti-interferon gamma therapy

AMG811

Amgen

Tumor necrosis factor therapy

Etanercept

NIAID/Florida Academic Dermatology Centers

Anti-B cell therapies

SBI-087 (anti-CD20 Small Modular ImmunoPharmaceutical)*

Wyeth/Trubion

 

Rituximab (anti-CD20)*

North Shore Hospital/Long Island Jewish

 

Epratuzumab (anti-CD22)*

UCB

 

Atacicept (TACI-Ig)*

EMD Serono

Anti-cytokine therapy 

Benlysta™ (Belimumab/anti-BLyS)*

Human Genome Sciences/GlaxoSmithKline

Anti-T cell therapies

Abatacept (CTLA4-Ig)*

Bristol-Myers Squibb

 

AMG557 (anti-B7RP-1)

Amgen

Immunomodulatory therapy

Lupuzor™ (IPP-201101)

Cephalon, Inc.

 

Paquinimod (ABR-215757) (an oral quinoline-3-carboximide)

Active Biotech Research

Immunosuppressive therapies

Elidel (pimecrolimus)

University of Leipzig

 

Tacrolimus

Seoul National University Hospital

 

Tacrolimus and mycophenolate mofetil

Tuen Mun Hospital

 

FK506 plus mycophenolate mofetil

Nanjing University School of Medicine

 

Sirolimus

NIDDK

 

Mycophenolate mofetil

LaRoche/Aspreva/Hospital Authority, Hong Kong/Oklahoma Medical Research Foundation

 

Lenalidomide (REVLIMID; thalidomide derivative)

University of Pennsylvania/Celgene

 

Rapamycin (Rapamune)

University of New York – Upstate Medical Center

Statins

Atorvastatin

Saint Luke’s Hospital

 

Simvastatin

Astra Zeneca/Ramathibodi Hospital

Other

Allogenic Mesenchymal stem cell transfer

Nanjing Medical University

Allogenic Blood Stem Cell Transplantation

NHLBI/Stanford University Medical Center

Vitamin D3 *

NIAID

N-acetylcysteine

State University of New York – Upstate Medical University

CC-10004 (apremilast; phosphodiesterase-4 inhibitor)

New York University School of Medicine/Celgene

Dehydroepiandrosterone (DHEA)

University of Michigan



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