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Treated SLE Patients Displayed Reduced Chemokine Biomarkers

February 12, 2014

Two chemokine biomarkers displayed significantly reduced levels in patients with systemic lupus erythematosus who were treated when compared with untreated patients, according to recent study results.

Researchers collected blood from 103 patients with systemic lupus erythematosus (SLE) and 65 healthy donors who were enrolled from 2008 to 2011 in the University of Florida Center for Autoimmune Diseases registry. Taqman real time polymerase chain reaction assays were used to isolate and analyze RNA samples from peripheral blood leukocytes for expression of mRNA and micro RNA. The delta delta C(T) method was used to determine relative expression of interferon signature genes, C-C motif chemokine ligand 2 (CCL2) and C-X-C motif chemokine 10 (CXCL10).

“Results were correlated with therapy using prednisone, mycophenolate mofetil and hydroxychloroquine and analyzed by Wilcoxon/Kruskal-Wallis test and Fisher’s exact test,” the researchers wrote.

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Source: Healio

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