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Sensitive Balance in the Immune System

April 11, 2014

As strange as it may seem, a process called "cellular suicide" is actually crucial for the survival of the entire body. The protein c-FLIPR plays a key role in controlling this process, which is called "apoptosis". Scientists at the Helmholtz Centre for Infection Research (HZI) have described the significance of c-FLIPR for the immune system in more detail: In the presence of an excess of this molecule, mice can fight infectious diseases better, but they develop autoimmune diseases as they get older. The inhibitory effect of c-FLIPR on apoptosis is the underlying cause of both these effects. The researchers published their results in "Cell Death & Disease".

Apoptosis is used by cells that are changed by disease or are simply not needed any longer to eliminate themselves before they become a hazard to the body—on a cellular level, death is part of life. Disruption of this process can lead to cancer or immunodeficiencies, but also to autoimmune diseases, in which cells attack their own body.

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Click here to read full article.

Source: Health Canal


Sensitive Balance in the Immune System

April 11, 2014

As strange as it may seem, a process called "cellular suicide" is actually crucial for the survival of the entire body. The protein c-FLIPR plays a key role in controlling this process, which is called "apoptosis". Scientists at the Helmholtz Centre for Infection Research (HZI) have described the significance of c-FLIPR for the immune system in more detail: In the presence of an excess of this molecule, mice can fight infectious diseases better, but they develop autoimmune diseases as they get older. The inhibitory effect of c-FLIPR on apoptosis is the underlying cause of both these effects. The researchers published their results in "Cell Death & Disease".

Apoptosis is used by cells that are changed by disease or are simply not needed any longer to eliminate themselves before they become a hazard to the body—on a cellular level, death is part of life. Disruption of this process can lead to cancer or immunodeficiencies, but also to autoimmune diseases, in which cells attack their own body.

***

Click here to read full article.

Source: Health Canal



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