HOME
Leading the way to a cure

LUPUS NEWS

New Therapeutic Approach Identified For Kidney Disease Associated With Lupus

January 26, 2010

Investigators have identified a new disease mechanism and therapeutic approach for a type of advanced kidney disease that is a common cause of complications in patients with lupus. The study was led by investigators at Hospital for Special Surgery and appears in the January 25 online Early Edition of the Proceedings of the National Academy of Sciences.

"The standard treatment for lupus kidney disease is to block inflammation," said Lionel Ivashkiv, M.D., associate chief scientific officer at Hospital for Special Surgery in New York City. "This study suggests you might want to target the macrophages, a specific type of white blood cell involved in the disease."

For years, clinicians have known that kidney damage occurs in many patients with lupus, and they have known how the disease triggers the start of kidney disease. Little has been known, however, about one type of lupus kidney disease, proliferative crescentic disease that is associated with adverse outcomes and decreased survival. This type of kidney disease is characterized by abnormal proliferation (growth) of kidney cells that leads to irreversible damage to internal kidney structures that help filter waste and fluids from the blood. This advanced kidney disease leads to kidney failure and it is an important cause of the need for dialysis and transplantation in lupus.

Previous studies have suggested that type I interferons are implicated in promoting the autoimmunity associated with lupus. "We were interested in understanding whether these interferons might work directly on the kidney," Dr. Ivashkiv said. "There is a lot of evidence that the interferons work on the immune system and we wanted to know how interferons affect kidney disease."

To investigate, researchers used a mouse model of lupus. By increasing interferon production, they caused advanced kidney disease to occur in the mice rapidly. "The mice are a strain that will get nephritis over time, but we injected the mice at the very onset of the disease thus causing a very accelerated pattern, so that the mice have complete renal failure in two to four weeks," Dr. Ivashkiv said. They then examined the changes that occurred during the development of the advanced kidney disease by drawing blood samples from the mice, and analyzing their kidneys, and analyzing the macrophages to determine their type, among other experiments.

In the type of kidney disease they were investigating, it has long been known that epithelial cells proliferating out of control form a kind of crescent. These crescent cells compress the glomerulus, the basic filtration unit of the kidney, and prevent it from functioning.

...

Read the full article here

Source medcompare.com


New Therapeutic Approach Identified For Kidney Disease Associated With Lupus

January 26, 2010

Investigators have identified a new disease mechanism and therapeutic approach for a type of advanced kidney disease that is a common cause of complications in patients with lupus. The study was led by investigators at Hospital for Special Surgery and appears in the January 25 online Early Edition of the Proceedings of the National Academy of Sciences.

"The standard treatment for lupus kidney disease is to block inflammation," said Lionel Ivashkiv, M.D., associate chief scientific officer at Hospital for Special Surgery in New York City. "This study suggests you might want to target the macrophages, a specific type of white blood cell involved in the disease."

For years, clinicians have known that kidney damage occurs in many patients with lupus, and they have known how the disease triggers the start of kidney disease. Little has been known, however, about one type of lupus kidney disease, proliferative crescentic disease that is associated with adverse outcomes and decreased survival. This type of kidney disease is characterized by abnormal proliferation (growth) of kidney cells that leads to irreversible damage to internal kidney structures that help filter waste and fluids from the blood. This advanced kidney disease leads to kidney failure and it is an important cause of the need for dialysis and transplantation in lupus.

Previous studies have suggested that type I interferons are implicated in promoting the autoimmunity associated with lupus. "We were interested in understanding whether these interferons might work directly on the kidney," Dr. Ivashkiv said. "There is a lot of evidence that the interferons work on the immune system and we wanted to know how interferons affect kidney disease."

To investigate, researchers used a mouse model of lupus. By increasing interferon production, they caused advanced kidney disease to occur in the mice rapidly. "The mice are a strain that will get nephritis over time, but we injected the mice at the very onset of the disease thus causing a very accelerated pattern, so that the mice have complete renal failure in two to four weeks," Dr. Ivashkiv said. They then examined the changes that occurred during the development of the advanced kidney disease by drawing blood samples from the mice, and analyzing their kidneys, and analyzing the macrophages to determine their type, among other experiments.

In the type of kidney disease they were investigating, it has long been known that epithelial cells proliferating out of control form a kind of crescent. These crescent cells compress the glomerulus, the basic filtration unit of the kidney, and prevent it from functioning.

...

Read the full article here

Source medcompare.com



1.5 million

people in the U.S. have Lupus.

100 million

dollars committed to lupus research by the Alliance for Lupus Research.


We're walking across the United States to raise awareness and funds for lupus research.

Can't make it? Join our National Virtual Walk to participate anytime, anywhere.


Show your support by visiting the Alliance for Lupus Research online store. Discover the perfect gift, or prepare for a walk with our selection of apparel and accessories.

Powered by Convio
nonprofit software