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New Antibody Shows Promise in Lupus

March 12, 2014

Initial clinical studies of epratuzumab in patients with active, moderate-to-severe systemic lupus erythematosus (SLE) are suggesting promise for this monoclonal antibody.

In an exploratory analysis of a 12-week phase IIb study, patients who received four weekly 600 mg doses of epratuzumab were three times more likely to show a response than those given placebo (OR 3.2, 95% CI 1.1-8.8, P=0.03), according to Daniel J. Wallace, MD, of the University of California Los Angeles, and colleagues.

"This product works quickly and it works in patients who are actively flaring, which is important," said co-investigator Vibeke Strand, MD, of Stanford University in Stanford, Ca.

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Click here to read full article.

Source: MedPage Today


New Antibody Shows Promise in Lupus

March 12, 2014

Initial clinical studies of epratuzumab in patients with active, moderate-to-severe systemic lupus erythematosus (SLE) are suggesting promise for this monoclonal antibody.

In an exploratory analysis of a 12-week phase IIb study, patients who received four weekly 600 mg doses of epratuzumab were three times more likely to show a response than those given placebo (OR 3.2, 95% CI 1.1-8.8, P=0.03), according to Daniel J. Wallace, MD, of the University of California Los Angeles, and colleagues.

"This product works quickly and it works in patients who are actively flaring, which is important," said co-investigator Vibeke Strand, MD, of Stanford University in Stanford, Ca.

***

Click here to read full article.

Source: MedPage Today



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