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Nanoparticles May Treat Autoimmune Disease

March 5, 2013

Lupus and other autoimmune diseases such as Type 1 diabetes may be cured with a novel method of drug delivery.

In a study published March 1 in The Journal of Clinical Investigation, Yale researchers found that delivering lupus drugs directly to specific immune cells using nanoparticles can extend the lifespan of mice infected with lupus. Without nanoparticle delivery, current drugs for lupus are short-lasting and require large doses to be effective, but this mode of delivery would require lower dosages of medication, said senior author Tarek Fahmy, associate professor of biomedical engineering at the Yale School of Engineering & Applied Science

“When you take the drug by itself, the drug molecules are diluted throughout the whole body, so that’s why you have to inject a lot more to get to the target cells,” Fahmy said. “You need a very high dose of the drug, but then there are a lot of side effects that complicate the disease and can make matters worse.”

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Click here to read the full article.

Source: Yale Daily News


Nanoparticles May Treat Autoimmune Disease

March 5, 2013

Lupus and other autoimmune diseases such as Type 1 diabetes may be cured with a novel method of drug delivery.

In a study published March 1 in The Journal of Clinical Investigation, Yale researchers found that delivering lupus drugs directly to specific immune cells using nanoparticles can extend the lifespan of mice infected with lupus. Without nanoparticle delivery, current drugs for lupus are short-lasting and require large doses to be effective, but this mode of delivery would require lower dosages of medication, said senior author Tarek Fahmy, associate professor of biomedical engineering at the Yale School of Engineering & Applied Science

“When you take the drug by itself, the drug molecules are diluted throughout the whole body, so that’s why you have to inject a lot more to get to the target cells,” Fahmy said. “You need a very high dose of the drug, but then there are a lot of side effects that complicate the disease and can make matters worse.”

***

Click here to read the full article.

Source: Yale Daily News



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