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Lupus & Arthritis: Steroids Research Yields Hearing Loss Treatment Clues

February 21, 2011

National Institutes of Health (NIH)-supported scientists will be presenting their latest research findings at the 2011 Midwinter Meeting of the Association for Research in Otolaryngology (ARO).

People who have an autoimmune disease—such as lupus or rheumatoid arthritis—also frequently experience hearing loss, and the conventional wisdom is that this is due to inflammation in the inner ear. As a result, most doctors will typically prescribe glucocorticoids, a family of steroids that quell the inflammation and improve hearing, but can have serious side effects if taken too long. NIDCD-funded researchers from Oregon Health & Science University see things a different way.
Their research shows that, although glucocorticoids may help improve hearing, they don’t seem to be acting on inflammation, which isn’t present in autoimmune mouse models with hearing loss. Rather, they seem to be correcting an imbalance in ions in the fluid of the inner ear, which is the more likely source of hearing loss.

In this study, the researchers looked at gene expression in autoimmune mice with hearing loss and found that 22 of the 24 genes regulating ion concentration in the inner ear were turned off. Genes that regulate the inflammatory response also were not activated, which is the opposite of what you’d expect to find if inflammation were involved. When the mice received glucocorticoid treatment, the expression of several ion-regulating genes significantly increased, while there was no effect on inflammation.


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Source healthyhearing.com