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Kidney Involvement, High Anti-dsDNA Predict Lupus Flares

July 2, 2013

Michelle A. Petri, M.D., from Johns Hopkins University in Baltimore, and colleagues conducted post-hoc analysis to assess baseline demographics, disease activity, and biomarkers in 562 patients, treated with standard therapy alone, with and without flare at treatment weeks 24/52. Severe and moderate flares were defined using the modified SLE Flare Index (SFI) and the new British Isles Lupus Assessment Group (BILAG) A/B scores.

The researchers found that over 52 weeks the frequencies of SFI, BILAG 1A, and BILAG 1A/2B flares were 24, 23, and 32 percent, respectively. Using all three indices, in univariate analyses, predictors of flares at weeks 24/52 included: Safety of Estrogens in Lupus Erythematosus National Assessment-SLE Disease Activity Index (SELENA-SLEDAI) ?12, anti-dsDNA positivity and proteinuria (?0.5 g/24 hours); BILAG renal, vasculitic, and hematologic scores; increased c-reactive protein; and B-lymphocyte stimulator (BLyS) ?2 ng/mL. In multivariate analysis, independent predictors at week 52 included: SELENA-SLEDAI/BILAG renal involvement and anti-dsDNA ?200 IU/mL (all three indices); SELENA-SLEDAI/BILAG neurologic and vasculitic involvement (BILAG A/2 B or 1A scores); BLyS ?2 ng/mL (SFI and BILAG 1A/2B scores); and low complement 3 (SFI).

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Source: Medical Xpress


Kidney Involvement, High Anti-dsDNA Predict Lupus Flares

July 2, 2013

Michelle A. Petri, M.D., from Johns Hopkins University in Baltimore, and colleagues conducted post-hoc analysis to assess baseline demographics, disease activity, and biomarkers in 562 patients, treated with standard therapy alone, with and without flare at treatment weeks 24/52. Severe and moderate flares were defined using the modified SLE Flare Index (SFI) and the new British Isles Lupus Assessment Group (BILAG) A/B scores.

The researchers found that over 52 weeks the frequencies of SFI, BILAG 1A, and BILAG 1A/2B flares were 24, 23, and 32 percent, respectively. Using all three indices, in univariate analyses, predictors of flares at weeks 24/52 included: Safety of Estrogens in Lupus Erythematosus National Assessment-SLE Disease Activity Index (SELENA-SLEDAI) ?12, anti-dsDNA positivity and proteinuria (?0.5 g/24 hours); BILAG renal, vasculitic, and hematologic scores; increased c-reactive protein; and B-lymphocyte stimulator (BLyS) ?2 ng/mL. In multivariate analysis, independent predictors at week 52 included: SELENA-SLEDAI/BILAG renal involvement and anti-dsDNA ?200 IU/mL (all three indices); SELENA-SLEDAI/BILAG neurologic and vasculitic involvement (BILAG A/2 B or 1A scores); BLyS ?2 ng/mL (SFI and BILAG 1A/2B scores); and low complement 3 (SFI).