March 22, 2011
Preeclampsia -- a dangerous condition marked by protein in the urine and high blood pressure during pregnancy -- complicates 4 percent to 5 percent of all pregnancies worldwide. If untreated, it threatens the health and lives of both mothers and babies.
Women with the autoimmune diseases systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are at increased risk for preeclampsia. This study included 250 pregnant women with either lupus or APS. Thirty of the women developed preeclampsia during the study, and 10 more had experienced preeclampsia during a previous pregnancy.
The researchers focused on specific genes [complement regulatory proteins membrane cofactor protein, or MCP, factor I and factor H] and found that seven of the 40 women had a mutation in one of these genes.
In addition, mutations in MCP or factor I were found in five of 59 women who did not have an autoimmune disease but who developed preeclampsia.
Source Bloomberg Businessweek.com