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Childhood-onset Lupus Brings Distinct Challenges at Each Phase of Life

January 1, 2014

Although pediatric rheumatologists care for disease entities distinct from those seen by adult rheumatologists, childhood-onset systemic lupus erythematosus (cSLE) and adult-onset SLE (aSLE) are fundamentally the same disease along a continuum. Important differences exist in disease manifestations, severity, and management that require consideration of the unique issues of the child and adolescent with chronic disease. SLE in childhood or adolescence accounts for 15% to 20% of all cases of SLE, with an approximate prevalence just below 1 per 10,000 children in the U.S.

The ACR classification criteria for SLE are used to classify patients with cSLE much as they are for aSLE, with one validation study demonstrating 96% sensitivity and 100% specificity in cSLE.1 The recently published Systemic Lupus International Collaborating Clinics (SLICC) classification criteria appear useful for cSLE, although they await systematic evaluation.

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Click here to read full article.

Source: The Rheumatologist


Childhood-onset Lupus Brings Distinct Challenges at Each Phase of Life

January 1, 2014

Although pediatric rheumatologists care for disease entities distinct from those seen by adult rheumatologists, childhood-onset systemic lupus erythematosus (cSLE) and adult-onset SLE (aSLE) are fundamentally the same disease along a continuum. Important differences exist in disease manifestations, severity, and management that require consideration of the unique issues of the child and adolescent with chronic disease. SLE in childhood or adolescence accounts for 15% to 20% of all cases of SLE, with an approximate prevalence just below 1 per 10,000 children in the U.S.

The ACR classification criteria for SLE are used to classify patients with cSLE much as they are for aSLE, with one validation study demonstrating 96% sensitivity and 100% specificity in cSLE.1 The recently published Systemic Lupus International Collaborating Clinics (SLICC) classification criteria appear useful for cSLE, although they await systematic evaluation.

***

Click here to read full article.

Source: The Rheumatologist



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