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SCIENTIFIC PUBLICATIONS BY ALR FUNDED RESEARCHERS

The role of nitric oxide in the antiphospholipid syndrome

Mineo, Chieko, PhD

University of Texas Southwestern Medical Center at Dallas

The anti-phospholipid syndrome (APS) is a common  autoimmune disease associated with blood clots, frequent miscarriages and an increased risk of coronary artery disease. Women with APS produce antibodies against phospholipids or their associated plasma proteins. However, the molecular mechanism by which these antibodies produce APS is unclear. 

Preliminary data from Dr. Mineo and her group show that anti-phospholipid antibodies (aPL Ab) prevent the activation of endothelial nitric oxide synthase (eNOS), an enzyme that produces nitric oxide. Nitric oxide is a key regulator of blood clots and vascular tension, enabling blood vessels to easily contract and expand. 

With their ALR grant, Dr. Mineo and her group will use  laboratory and animal models to try and determine the  mechanism by which aPL Ab impinges upon the normal  activation processes of eNOS. 

What this study means for people with lupus: Understanding the underlying mechanism of APS will, hopefully, lead to novel preventative and treatment- oriented therapies for APS and contribute to our overall  understanding of the immune system and its effect on  various physical systems. 


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