Protective roles of ETS1 in SLE
Ho, I-Cheng, MD, PhD
Brigham and Women's Hospital, Inc.
Researchers have identified numerous genes related to the lupus and other autoimmune diseases. Now they are moving onto the next step—using that knowledge to identify new targets for treatment. Dr. Ho and his team used their ALR one-year, pilot grant to explore the role of a newly identified gene called ETS1 that is associated with the risk of lupus. They theorized that the gene can counteract the pathology of the disease by inhibiting production of the inflammatory molecule interleukin 10 (IL-10). People with lupus have unusually high levels of IL-10 in their blood, which is thought to contribute to the development of the disease and its symptoms. The work they were able to do thanks to the ALR grant enabled Dr. Ho and his team to obtain a much-larger, three-year grant from the Department of Defense that will allow them to continue their research into the role of ETS1 in lupus.
What this study means for people with lupus: Results from this study may help identify new targets for lupus treatments.