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SCIENTIFIC PUBLICATIONS BY ALR FUNDED RESEARCHERS

Platelet C4d is Highly SPecific for Systemic Lupus Erythematosus

Ahearn, Joseph, MD

University of Pittsburgh

June 1, 2006

Complement-activation product C4d is deposited on normal erythrocytes, while abnormal levels have been observed on the surface of erythrocytes of patients with systemic lupus erythematosus (SLE). This study examines whether C4d also deposits on human platelet surfaces, and whether platelet-bound C4d may provide a biomarker for SLE.

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