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SCIENTIFIC PUBLICATIONS BY ALR FUNDED RESEARCHERS

Novel Approach to Modeling the Functional Genomics of Human SLE in Mice

Roopenian, Derry, PhD

Jackson Laboratory

Like most autoimmune syndromes, the genetic predisposition to lupus is complex. We see this complexity in genetic association studies that have identified anomalies in more than 30 genes that provide small, but significant, contributions to the disease. However, only when several of these genetic variations occur simultaneously does the disease itself result. Thus, it is difficult to translate these complex genetic patterns into a biological explanation of the specific anomalies that cause lupus, and even more challenging to apply this information to benefit people with lupus.

With their grant, Dr. Roopenian and his team will use a mouse model to explore these issues. They will mimic the genetic changes seen in humans with lupus in the mouse and observe the results of such abnormalities. They will combine this information with gene expression studies to discover the molecular pathways that determine susceptibility and resistance to lupus in mice. 

What this study means for people with lupus: Conducting studies in mice to specifically address genes we already know affect the risk of lupus in humans should provide important information for predicting, understanding, and treating lupus and related disorders in humans.


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