Leading the way to a cure


Kallikreins in Lupus Nephritis

Mohan, Chandra, MD

University of Texas Southwestern Medical Center at Dallas

The pathogenic mechanisms leading to kidney disease, or nephritis, in lupus remains unclear. Likewise, the molecules that determine the degree of kidney damage in lupus are also unknown. Recently, Dr. Mohan and his team highlighted kallikreins as potential candidate genes and disease modifying agents in lupus nephritis. Kallikreins are enzymes that can modulate several disease pathways in the kidneys as well as other tissues. 

With this grant, they plan to determine the importance of  kallikreins in lupus nephritis and to sequence the kallikrein genes in mouse and human lupus. These studies will shed light on the genetics of lupus nephritis, increase our  understanding of the pathogenic origins of lupus nephritis, and provide new targets for therapeutic treatments. 

What does this study mean for people with lupus: This study may identify an entirely new mechanism for lupus nephritis, providing numerous new targets for future treatments and preventive strategies.

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