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SCIENTIFIC PUBLICATIONS BY ALR FUNDED RESEARCHERS

Identification of Novel Genes in Childhood-Onset SLE

Jacob, Chaim, MD, PhD

USC/University of Southern California

Dr. Jacob’s project is the first large-scale genetic study  concentrating on childhood-onset lupus. His earlier work  suggested novel lupus-associated genes. He is now using his ALR grant to conduct a study of patients with childhood-onset lupus to discover genes responsible for the disease and identify the exact disease mutations and their functional relevance. 

In addition, Dr. Jacob and his team will test whether genetic associations in childhood-onset lupus can be replicated in adult-onset lupus subjects, ascertaining whether the same genes are associated with both types of lupus. 

What this study means for people with lupus: The findings may lead to the development of therapeutic approaches targeting relevant molecules and help researchers identify genetic markers to identify lupus patients who would benefit most from such therapeutic options.


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