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SCIENTIFIC PUBLICATIONS BY ALR FUNDED RESEARCHERS

Genes from SLEGEN, the Lupus Genetics Consortium

Harley, John, MD, PhD

Oklahoma Medical Research Foundation

The ALR-supported International Lupus Genetics Consortium (SLEGEN) has published its work demonstrating 13 genes associated with lupus. In addition, it is clear that many additional genetic effects are important in lupus, with some evidence suggesting more than 100 genes are involved. Dr. Harley and his team have focused their efforts on genes that appear to be involved in lupus, but for which convincing evidence is still lacking. 

With this grant, they will work to replicate the evidence for genetic involvement in more than 12,000 people of European, African, Hispanic and Asian descent. Their goal is to explain how genetic differences work at the level of DNA differences between individuals. The genetic basis of the disease could then be used to develop new diagnostic tests and new therapies that, hopefully, will work better at preventing and treating lupus than current options. 

What this study means for people with lupus: It will enhance our understanding of lupus to allow the development of new diagnostic, therapeutic and preventive strategies, as well as help usher in the era of personalized medicine for people with the disease.


1.5 million

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100 million

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