Leading the way to a cure


Functional Analysis of IFN-a Regulated OAS1 Overexpression in Cutaneous LE

Sinha, Animesh A., MD, PhD

Michigan State University

Disfiguring and debilitating skin lesions in cutaneous lupus patients not only represent symptoms of the disease, but also play an integral part in the induction of autoimmunity. Preliminary data from Dr. Sinha and his team suggest that interferon-regulated genes, including the 9-2 isoform of OAS1, may play a role in lupus by disrupting the normal pathways that regulate cell death.  

With the Pilot grant, the researchers hope to learn if changes in the expression of OAS1 genes and proteins contribute to abnormalities in cellular death pathways, leading to the induction and maintenance of the autoimmune state in cutaneous lupus.  

What this means for people with lupus: Identifying genetic contributions to autoimmunity in cutaneous lupus may provide new markers to target with therapeutic treatments. 

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