Leading the way to a cure


Function2Gene: A gene selection tool to increase the power of genetic association studies by utilizing public databases and expert knowledge - Chaim O Jacob

July 17, 2008

Background: Many common disorders have multiple genetic components which convey increased susceptibility. SNPs have been used to identify genetic components which are associated with a
disease. Unfortunately, many studies using these methods suffer from low reproducibility due to lack of power.

Results: We present a set of programs which implement a novel method for searching for diseaseassociated genes using prior information to select and order genes from publicly available databases
by their prior likelihood of association with the disease. These programs were used in a published study of childhood-onset SLE which yielded novel associations with modest sample size.

Conclusion: Using prior information to decrease the size of the problem space to an amount commensurate with available samples and resources while maintaining appropriate power enables
researchers to increase their likelihood of discovering reproducible associations.


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Source: Alliance for Lupus Research
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