Leading the way to a cure


Altered T Follicular Helper Cell Subsets In Active Pediatric Lupus

Ueno, Hideki, MD, PhD

Baylor Institute for Immunology Research

Uncontrolled generation of autoantibodies is a hallmark of lupus. Animal studies show that a type of helper T cells, called T follicular helper (Tfh) cells, contribute to the development of the disease and the dysfunctional autoantibodies. Yet, very little is known about whether Tfh cells play a role in the development of human lupus. 

Preliminary data from Dr. Ueno and his team suggest that Tfh cells do play a role in lupus development. With their ALR grant, they plan to determine how these cells differ in quality and quantity in pediatric lupus patients from those in healthy children. They will also investigate whether such alterations correlate with disease severity and/or specific organ damage. 

What this study means for people with lupus: This project will establish a cornerstone for the team’s long-term goal, which is to develop novel therapeutic approaches for lupus that reprogram altered Tfh responses.

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