Leading the way to a cure

Lupus Research Update: 2011 Volume 2

Volume 2, 2011 - Online Edition | In This Issue

Advances in Understanding Pregnancy and Lupus >
Lowering the Risk of Pregnancy Loss >
Faces of Lupus: Pregnancy and Lupus >

Lowering the Risk of Pregnancy Loss

Vikki M. Abrahams, Ph.D., Associate Professor of Obstetrics, Gynecology, and Reproductive Sciences at the Yale School of Medicine, is one of the scientists who have received ALR funding to advance our understanding of lupus and pregnancy.

Vikki Abrahams, MD Dr. Abrahams has been investigating a specific condition in women with lupus, the antiphospholid syndrome that is known to cause miscarriage and stillbirth. This syndrome is a coagulation disorder of the blood that also leads to excessive blot clotting.

During pregnancy antiphospholipid antibodies appear to target cells of the developing placenta, disrupting the normal cell functions. These disruptions kill cells and inflame the area where the placenta would normally attach to the uterus, and these destructive changes greatly increase the risk of pregnancy loss.

A key goal of Dr. Abrahams’s research is to find the precise mechanisms that put women with lupus at risk for antiphospholid syndrome.

What does this mean for women with lupus? This study may lead to better methods of diagnosing the likelihood of pregnancy complications and developing new treatments to improve the long-term health of mother and fetus.

1.5 million

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