Volume 3, 2009 - Online Edition | In This Issue
Ten Extraordinary Years of Growth and Discovery >
Building on Our Advances in Genome Science >
Paving the Future with Cutting Edge Research >
Message from the President >
Where There is a WILL ... There is a Way to End Lupus >
The Face of Lupus: Fighting the Disease on Many Fronts >
Double the Impact of Your Generosity >
Supporting Our Lupus Research Update >
Shoe News: A Doctor Who is Also a Lupus Patient >
It's time to put on your Walking Shoes >
Federal Employees Make a Real Difference >
Building on Our Advances in Genome Science
Innovative and groundbreaking, the ALR-funded International SLE Genetics Consortium (SLEGEN) achieved monumental results. Today we possess a fundamental knowledge of this disease thanks to ALR-funded researchers who announced in 2008 that they had identified genetic markers for lupus.
SLEGEN Co-Director John B. Harley, M.D., Ph.D., explains that "The ALR has been the essential convener ... making far-seeing investments in research — and the world has been richly rewarded."
What does this mean for the future? According to Dr. Harley "Our next big challenge will be to discover why these genes cause lupus and in this context we will be investigating regional ancestries."
Dr. Harley provides the details: "As 80 percent of the DNA variations between individuals can be attributed to their ancestry we are comparing where lupus patients come from, we hope to pinpoint genes that may add to the risk of developing lupus."
More good news: this fundamental breakthrough has been awarded a $10 million grant from the National Institutes of Health for extended research.