Leading the way to a cure

Lupus Research Update: 2007 Volume 1

Volume 1, 2007 - Online Edition | In This Issue

The results are in! >
ALR's 2007 grant recipients >
One Love. One Cause. ALR Gala a Smashing Success >
The Faces of Lupus >
Advocacy Update — ALR Goes to Washington >
Research Results - Rituximab Results in Long-Term Immune Alteration in Some Lupus Patients >
Research Results — Exploring Toll-Like Receptors’ (TLR) Role in Lupus >
Research Results – The Role of Myeloid Dendritic Cells in Lupus >
News Flash – American College of Rheumatology Annual Meeting Update >
FDA Warning on Rituximab >
Drug Research and Development News >
Beyond the Research - 2007 Walk Sites Announced >

Here is a list* of the ALR’s 2007 grant recipients:

Jill P. Buyon, M.D.,
Associate Director, Division of Rheumatology, Department of Medicine, New York University School of Medicine
Grant award: TK
Grant title: Preventive IVIGTherapy for Congenital Heart Block (PITCH)

John Hardin, M.D., Professor
of Medicine, Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, New York
Grant award: $498,398
Grant title: Vitamin D in lupus

Jacob Chaim, M.D., Ph.D.,
Associate Professor of Medicine, University of Southern California, Los Angeles, CA
Grant award: $480,672
Grant title: Identification of novel genes in childhood onset SLE

Matthias Kretzler, M.D.,
Associate Professor of Internal Medicine, the Regents of the University of Michigan, Ann Arbor, MI
Grant award: $423,366
Grant title: Gene expressionbased molecular classification of lupus nephritis biopsies

Chieko Mineo, Ph.D.,
Assistant Professor, University of Texas Southwestern Medical Center at Dallas
Grant award: $478,697
Grant title: The role of nitric oxide in the antiphospholipid syndrome

Andras Perl, M.D., Ph.D.,
Professor, SUNY Upstate Medical University, Syracuse, NY
Grant award: $434,354
Grant title: Mitochondrial hyperpolarization in lupus t cells

Alessandra B. Pernis, M.D.,
Associate Professor of Medicine, Columbia University Medical Center, New York
Grant award: $434,322
Grant title: Role of Rho GTPases and their activators in lupus pathogenesis

Lars Edvard Rönnblom, M.D., Ph.D.,
Professor, Uppsala University, Uppsala, Sweden
Grant award: $467,078
Grant title: Type I interferon system genes in the etiopathogenesis of SLE

Bruce T. Volpe, M.D.,
Professor of Neurology & Neurosciences, Cornell Medical College, Winifred Masterson Burke Medical Research Institute,
White Plains, NY
Grant award: $426,522
Grant title: Developmental neurotoxicity of maternal lupus anti-NMDAR antibodies

Edward K. Wakeland, Ph.D.,
Professor and Director, Center for Immunology The University of Texas Southwestern Medical Center at Dallas
Grant award: $489,630
Grant title: Genes and genetic pathways that modulate SLE

Richard Bucala, M.D., Ph.D.,
Professor of Medicine, Yale University
Grant award: $897,442 (renewal)
Grant title: MIF Inhibition in SLE

Stephen Tomlinson, Ph.D.,
Professor, Medical University of South Carolina, Charleston
Grant award: $648,518 (renewal) Note: Funding for Dr. Tomlinson’s grant is contingent upon negotiations with the Department of Defense’s Peer Reviewed Medical Research Program.
Grant title: The complement system as a therapeutic target for lupus

Jennifer Anolik, M.D., Ph.D.,
Assistant Professor, University of Rochester, NY
Grant award: $75,000
Grant title: Biomarkers in SLE patients undergoing B cell depletion therapy

Jane Buckner, M.D.,
Associate Member, Benaroya Research Institute at Virginia Mason, WA
Grant award: $50,000
Grant title: Induction of regulatory T cells for the treatment of lupus

David Daikh, M.D., Ph.D.,
ResearchScientist, Northern California Institute for Research and Education, CA
Grant award: $50,000
Grant title: Isolation and expansion of regulatory T cells from patients with SLE

Anselm Hennis, Ph.D., MBBS,
Director, Chronic Disease Research Centre, Barbados
Grant award: $74,750
Grant title: Risk Factors for Health Disparities in SLE Nephritis

Laura Julian, Ph.D.,
Assistant Professor, Department of Medicine The Regents of the University of California, San Francisco, CA
Grant award: $75,000
Grant title: Memory impairment and depression in SLE: Role of NMDA receptors

Kyriakos Kirou, M.D.,
Assistant Scientist and Assistant Attending, The Hospital for Special Surgery, NY
Grant award: $75,000
Grant title: IFN-alpha pathway activation as a biomarker of disease activity

S. Sam Lim, M.D.,
Chief ofRheumatology, Grady Health Systems, Emory University, GA
Grant award: $75,000
Grant title: The GOAL of organizing patients against lupus

Chandra Mohan, M.D., Ph.D.,
Professor, University of Texas Southwestern Medical Center at Dallas, TX
Grant award: $75,000
Grant title: Glomerular bullets in lupus

Tamara Nowling, Ph.D.,
Assistant Professor, Medical University of North Carolina, NC
Grant award: $60,000
Grant title: Function of a polymorphism in the Fli1 promoter and association
with lupus

Animesh Sinha, M.D., Ph.D.,
DivisionHead, Michigan State University, MI
Grant award: $75,000
Grant title: Functional analysis of IFN-α regulated OAS1 overexpression in cutaneous LE

Tianfu Wu, Ph.D.,
Assistant Professor, University of Texas Southwestern Medical Center at Dallas, TX
Grant award: $75,000
Grant title: Use of iTRAQ to identify early biomarkers in lupus urine

* This listing of 2007 awards is for informational purposes only. Identification of the list of awardees is not intended to either confer a right to funding nor does it guarantee funding. The award of funds is contingent upon successful negotiations.

1.5 million

people in the U.S. have Lupus.

106 million

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